Chinese cohort study of chronic kidney disease： design and methods

作     者：Gao Bixia Zhang Luxia Wang Haiyan Zhao Minghui On behalf of the Chinese Cohort Study of Chronic KidneyDisease (C-STRIDE) 

作者机构：Renal Division Department of Medicine Peking University First Hospital Peking University Institute of Nephrology Key Laboratory of Renal Disease Ministry of Health of China Key Laboratory of Chronic Kidney Disease Prevention and Treatment(Peking University) Ministry of Education Beijing 100034 China 

基　　金：The C-STRIDE is supported by the grants from the Research Special Fund for Public Welfare Industry of Health from the National Health and Family Planning Commission of the People's Republic of China (No.201002010) the National Key Technology R&D Program of the Ministry of Science and Technology (No.2011BAI10B01) and the Establishment of Early Diagnosis Pathway and Model for Evaluating Progression of Chronic Kidney Disease (No.D131100004713007) from the Beijing Science and Technology Committee 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2014年第127卷第11期

页      码：2180-2185页

摘      要：Background Chronic kidney disease （CKD） is a common disorder associated with multiple adverse clinical consequences,especially cardiovascular risk and end-stage renal disease.A recent national survey demonstrated that CKD has become a leading health problem in *** is an urgent need to implement an in-depth investigation of the CKD burden and also to explore underlying mechanisms of CKD progression and it association with adverse *** The Chinese Cohort Study of Chronic Kidney Disease （C-STRIDE） is the first national CKD cohort in *** will enroll approximately 3 000 pre-dialysis CKD patients aged between 18 and 74 years and follow-up for at least 5 ***,anthropometric measures,laboratory tests,and biomaterials will be collected at baseline and *** principal clinical outcomes of the C-STRIDE consist of renal disease events,cardiovascular events,and *** on the longitudinal clinical data and biomaterials,the risk factors with CKD progression and other outcomes will be analyzed,and candidate markers and predicted models will be *** The C-STRIDE would provide important evidence for underlying mechanisms of CKD progression,valuable information for clinical guidelines,and healthcare policies in China.

主 题 词：biomarkers chronic kidney disease cohort China risk factors 

学科分类：0710[理学-生物科学类] 07[理学] 0906[农学-水产类] 09[农学] 071007[071007] 

核心收录：

D　O　I：10.3760/cma.j.issn.0366-6999.20132906

馆 藏 号：203150390...