Heart‘omicsin’AGEing (HOMAGE):design,research objectives and characteristics of the common database
作者机构：Studies Coordinating CentreResearch Unit Hypertension and Cardiovascular EpidemiologyKU Leuven Department of Cardiovascular SciencesUniversity of Leuven Centre d'Investigation Clinique Pierre Drouin and U 961Hypertension and Heart Failure UnitInstitut Lourrain du Coeur etdes VaisseauxInsermNancyFrance Department of Anesthesiology and Critical Care MedicineInsermUMR-S942Hopital LariboisiereUniversite Paris Diderot Equipe obesite et insuffisance cardiaqueUniversite UPSInserm I2MCUMR 1048ToulouseFrance InsermU744CHRULilleFrance Department of CardiologyMedical University Graz Cardiovascular InstituteUniversity of ManchesterManchesterUK Division of Cardiovascular SciencesFoundation for Applied Medical ResearchUniversity of Navarra Heart Failure UnitSt Vincent's University Hospital University College Dublin Department of CardiologyUniversity of HullUK Department of CardiologyMaastricht University Medical CentreNetherlands Center for Heart Failure ResearchDepartment of CardiologyMaastricht UniversityNetherlands Department of Cardiovascular ResearchIRCCS - Istituto di Ricerche Farmacologiche "Mario Negri" International Center for Circulatory HealthImperial College Institute of Cardiovascular and Medical SciencesBHF Glasgow Cardiovascular Research CenterUniversity of Glasgow London School of Hygiene and Tropical Medicine
出 版 物：《The Journal of Biomedical Research》 (生物医学研究杂志（英文版）)
年 卷 期：2014年第28卷第5期
页 码：349-359页
摘 要：Heart failure is common in older people and its prevalence is *** Heart ＇omics＇ in AGEing（HOMAGE） project aims to provide a biomarker approach that will improve the early diagnosis of heart failure.A large clinical database,based on（1） prospective population studies or（2） cross-sectional,prospective studies or randomized controlled trials（RCTs） of patients at risk for or with overt cardiovascular disease will be constructed to determine most promising ＇omics＇-based biomarkers to identify the risk of developing heart failure and/or *** studies,patient cohorts and RCTs are eligible for inclusion in the common database,if they received ethical approval to obtain and share data and have baseline information on cardiovascular risk ***,the HOMAGE database includes 43,065 subjects,from 20 studies in eight European countries,including healthy subjects from three population studies in France,Belgium and Italy（n = 7,124）,patients with heart failure（n = 4,312） from four cohorts in the UK,Spain and Switzerland and patients at high risk for cardiovascular disease（n = 31,629） in 13 *** is anticipated that more partners will join the consortium and enlarge the pooled *** large merged database will be a useful resource with which to identify candidate biomarkers that play a role in the mechanism underlying the onset and progression of heart failure.
主 题 词：left ventricle heart failure heart failure with reduced ejection fraction heart failure with preserved ejection fraction population science morbidity mortality
学科分类：1002[医学-临床医学类] 100201[100201] 10[医学]
D O I：10.7555/JBR.28.20140045
馆 藏 号：203153496...
