Computational Screening of Novel Mitogen-activated Protein Kinase Kinase-1 （MEK1） Inhibitors by Docking and Scoring

作     者：Po-Yuan Chen Hong-Jye Hong Mien-De Jhuo Tzu-Hurng Cheng Wei-Tse Hsu Chieh-Hsi Wu Che-YenOu Yeng-Ting Yui Jing-Pin Lin Jing-Gung Chung 

作者机构：Department of Biological Science and Technology China Medical University Taichung 40402 Taiwan College of Chinese Medicine China Medical University Taichung 40402 Taiwan Schools of Pharmacy and Chinese Medicine China Medical University Taichung 40402 Taiwan Departments of Biotechnology Asia University Taichung 40402 Taiwan 

出 版 物：《Journal of Life Sciences》 (生命科学（英文版）)

年 卷 期：2011年第5卷第6期

页      码：434-442页

摘      要：The mitogen-activated protein kinase （MAPK） cell signal transduction pathways play a key role in determining the survival of cells. If these pathways can be controlled, they will prohibit the proliferation of cancer cells. To attain this goal, the authors utilize many drugs to interact with mitogen-activated protein kinase kinase-1 （MEK1） in MAPK, and use computer aided drug design （CADD） to analyze the ligand activities of proteins in MEKL The results show that in these drugs, the aromatic group in the terminal of the protein and the PHE209 will induce the stacking force, which is highly related to the actual activities of these drugs.

主 题 词：Docking and scoring computational screening mitogen-activated protein kinase kinase-1 (MEK1). 

学科分类：0710[理学-生物科学类] 07[理学] 081203[081203] 08[工学] 071009[071009] 09[农学] 0835[0835] 0901[农学-植物生产类] 090102[090102] 0812[工学-测绘类] 

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