Site-selective benzylic C–H oxidation through mediated electrolysis

作     者：Yi-Fan Xi Rui-Xing Gao Ping Fang Ya-Ping Han Cong Ma Tian-Sheng Mei 奚亦凡;高睿行;方萍;韩亚平;马聪;梅天胜

作者机构：State Key Laboratory of Organometallic ChemistryShanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032China School of Chemical Engineering and TechnologyHebei University of TechnologyTianjin 300130China 

基　　金：国家重点研发计划(2021YFA1500100) 

出 版 物：《Chinese Journal of Catalysis》 (催化学报(英文))

年 卷 期：2024年第67卷第12期

页      码：54-60页

摘      要：A novel strategy for site-selective benzylic C–H oxidation has been developed through mediated electrolysis.A bulky maleimide N-oxyl radical(MINO)generated by proton-coupled electrochemical oxidation of N-hydroxymaleimide(NHMI),serves as a hydrogen atom-transfer ***-to-excellent site selectivity was observed among different substrates,providing a practical approach for site-selective benzylic C–H ***,the hydrogen-atom transfer mechanism for C–H electrochemical oxidation allows the oxidation to proceed at much lower anode potentials relative to direct electrolysis and with minimal reliance on the substrate s electronic properties.

主 题 词：Organic electrochemistry Hydrogen atom transfer Site-selective oxidation N-Hydroxymaleimide Radical oxidation 

学科分类：08[工学] 080502[080502] 0805[工学-能源动力学] 

核心收录：

D　O　I：10.1016/S1872-2067(24)60139-7

馆 藏 号：203155699...