Microneedles for non-transdermal drug delivery:design strategies and current applications

作     者：Jinhong Xu Xiangyi Liao Danli Chen Xiuzhuo Jia Xufeng Niu 许锦红;廖相宜;陈丹藜;贾秀镯;牛旭锋

作者机构：Department of PharmacyThe Fourth Central Hospital of Baoding CityBaoding 072350China Key Laboratory of Biomechanics and Mechanobiology(Beihang University)Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China Department of Medical BusinessThe Fourth Central Hospital of Baoding CityBaoding 072350China 

基　　金：financial support from the Beijing Natural Science Foundation(No.L234020) the National Natural Science Foundation of China(Nos.12472325 and 12272032) the 111 Project(No.B13003) 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造(英文))

年 卷 期：2025年第8卷第2期

页      码：243-274,I0003页

摘      要：Microneedles(MNs)are an innovative and viable option for drug delivery that offer the distinct advantages of minimal invasiveness,painlessness,stable drug loading,efficient drug permeation,and *** were first used to penetrate the skin surface and facilitate transcutaneous drug delivery with great *** applications of MNs have extended to non-transdermal drug delivery,specifically,to various tissues and *** review captures the fabrication methods for MNs,discusses advanced design strategies for achieving controlled drug release,and summarizes current MN applications in delivering multiple therapeutic agents to the cardiovascular,digestive(e.g.,oral cavity),reproductive,and central nervous *** findings in this review would contribute toward the improved designs of MN systems that can be modified according to purpose,including material selection,structural design,choice of fabrication methods,and tissue considerations,to determine the optimal therapeutic regimen for the target treatment area.

主 题 词：Microneedles(MNs) Biocompatible materials Non-transdermal drug delivery Controlled release 

学科分类：08[工学] 080502[080502] 0805[工学-能源动力学] 

核心收录：

D　O　I：10.1631/bdm.2300352

馆 藏 号：203157964...