Design and evaluation of aceclofenac ocular inserts with special reference to cataracts and conjunctivitis

作     者：Vivek Dave Sachdev Yadav Sarvesh Paliwal Swapnil Sharma Dhirendra Kumar 

作者机构：Department of Pharmacy Banasthali University Manipal College of Pharmaceutical Sciences 

出 版 物：《Journal of Chinese Pharmaceutical Sciences》 (中国药学（英文版）)

年 卷 期：2013年第22卷第5期

页      码：449-455页

摘      要：The eyes present unique opportunities and challenges when it comes to the delivery of *** absorption by this route is bungling,there are a few side effects with conventional dosage *** inserts were prepared with prolonged release of drug and minimum swelling within cul-de-sac using *** work focused on treatment of conjunctivitis and cataracts by formulating ocular inserts of different polymeric combination of aceclofenac using hydroxypropyl methyl cellulose(HPMC,3% to 5%),chitosan(3% to 5%),poly vinyle alcohol(PVA,3% to 5%),methyl cellulose(MC,3% to 5%) as drug reservoir and ethyl cellulose(EC) polymer as rate controlling membrane by solvent casting technique with the objective of increasing contact time,achieving controlled release and greater therapeutic *** prepared ocular insert were then evaluated for physical appearances tensile strength,elongation at break(%),weight variation,uniformity of thickness,moisture absorption(%),pH,folding endurance,Fourier Transform Infrared spectroscopy,differential scanning *** characterization and in vitro transcorneal permeation studies reveals that,the prepared ocular insert formulations F2 and F8 containing HPMC and PVA had released their drug content,98.54% and 96.24%,respectively,over an extended period of 24 *** these formulations were selected as best optimized *** can be concluded that hydroxy propyl methyl cellulose is a good film forming hydrophilic polymer which shows potential agent for ocular drug delivery *** of polyethylene glycol enhances the permeability of aceclofenac ocular insert and has perfect zero order release,proving a promising controlled release delivery system.

主 题 词：Transcomeal Nasolacrimal Rate controlling membrane Drug reservoir 

学科分类：1002[医学-临床医学类] 100212[100212] 10[医学] 

核心收录：

D　O　I：10.5246/jcps.2013.05.066

馆 藏 号：203165739...