Improving the sensitivity for DNA sensing based on doubleanchored DNA modified gold nanoparticles

作     者：Xiaozhou Ma Miao Wang Chun Chen Mark Antonin Isbell Rui Wang Dongsheng Liu Zhongqiang Yang 

作者机构：Key Laboratory of Preclinical Study for New Drugs of Gansu ProvinceState Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular BiologySchool of Basic Medical ScienceLanzhou UniversityLanzhou 730000China Key Laboratory of Organic Optoelectronics&Molecular Engineering of the Ministry of EducationDepartment of ChemistryTsinghua UniversityBeijing 100084China Department of Chemistry and Chemical BiologyCornell UniversityIthaca 14850USA Department of Chemical EngineeringImperial College LondonLondon SW7 2AZUK 

基　　金：supported by the National Basic Research Program of China (2013CB932803) the National Natural Science Foundation of China (91427302, 21421064) the National Natural Science Foundation of China-Deutsche Forschungsgemeinschaft (NSFC-DFG) joint project TRR61 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2016年第59卷第6期

页      码：765-769页

摘      要：DNA modified nanoparticles(Au NPs) are an established and widely used type of nucleotide sensor. We sought to improve the design by applying short rigid DNA duplexes near the surface of the Au NPs forming a so called double-anchored Au NP sensor, and compared it with other conventional DNA modified Au NPs. The improved design exhibited higher assembly efficiency, and consequently increased its sensitivity to target DNA.

主 题 词：金纳米粒子 DNA检测 DNA修饰 灵敏度 改进设计 金纳米颗粒 传感器 核苷酸 

学科分类：0710[理学-生物科学类] 071010[071010] 081704[081704] 07[理学] 08[工学] 0817[工学-轻工类] 0703[理学-化学类] 

核心收录：

D　O　I：10.1007/s11426-016-5572-5

馆 藏 号：203178005...