胎儿胸腺萎缩:胎儿炎症反应综合征的超声标志

作     者：Di Naro E. Cromi A. Ghezzi F. 李奎 

作者机构：Department of Obstetrics and Gynecology University of Insubria Del Ponte Hospital Piazza Biroldi 1 21100 Varese Italy Dr. 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2006年第2卷第4期

页      码：10-10页

摘      要：Objective: The purpose of this study was to evaluate whether there is a relationship between the sonographic fetal thymus size and the presence of an intrauterine infection in patients with preterm labor. Study design: Thirty-one women who had been admitted with preterm labor and intact membranes between 24 and 32 weeks of gestation were included. Fetal thymus perimeter was measured sonographically, and amniocentesis for the microbiologic assessment of the amniotic cavity was performed. Placentas and umbilical cords were examined for the presence of chorioamnionitis/funisitis. Results: The prevalence of preterm delivery and intra-amniotic infection was 51.6%(16/31 women) and 32.3%(10/31women), respectively. In all cases with intrauterine infection and in 23.8%of cases without intrauterine infection, the fetal thymus perimeter was below the 5th percentile for gestational age (10/10 women vs 5/21 women; P < .01). Isolated histologic chorioamnionitis and funisitis were found in 22.6%and 25.8%of fetuses, respectively. The fetal thymus was below the 5th percentile for gestational age in 100%, 71.4%, and 12.5%of patients with histologic signs of funisitis and isolated chorioamnionitis and without histologic signs of infection, respectively. Conclusion: Fetal thymus involution in preterm labor patients is strongly associated with funisitis, which is the histologic manifestation of the fetal inflammatory response syndrome.

主 题 词：胸腺萎缩 炎症反应综合征 羊水穿刺 羊膜腔 绒毛膜羊膜炎 宫内感染 先兆早产 脐带炎 研究设计 

学科分类：1002[医学-临床医学类] 100211[100211] 10[医学] 

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