Rational design of multi-targeting ruthenium-and platinum-based anticancer complexes
作者机构：Beijing National Laboratory for Molecular SciencesCAS Key Laboratory of Analytical Chemistry for Living BiosystemsNational Centre for Mass Spectrometry in BeijingInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of SciencesBeo'ing 100049China
基 金：supported by the National Natural Science Foundation of China(21135006,21127901,21275148,21301181,21321003,21575145) the National Basic Research Program of China(2013CB531805)
出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)
年 卷 期：2016年第59卷第10期
页 码：1240-1249页
摘 要：Platinum-based anticancer drugs, including cisplatin and its analogues, have played important roles in the clinical treatment of solid tumors over the past 38 years. However, poor selectivity, high toxicity and intrinsic or acquired drug resistance profoundly limit their application, which encourages the development of novel transition metal-based anticancer agents with different mechanisms of action. To this end, transition metal complexes that can simultaneously act on more than one target, termed as single-molecule multi-targeting complexes, have attracted increasing attention because of their enhanced efficacy and diminished chance of drug resistance. In this review, we systematically discuss the recent progress in the development of platinum- and ruthenium-based anticancer agents, in particular the rational design of platinum and ruthenium complexes with multi-targeting features.
主 题 词：anticancer agents metal complexes multi-targeting EGFR-inhibition DNA binding
学科分类：081704[081704] 0907[农学-草药学] 07[理学] 070304[070304] 08[工学] 0817[工学-轻工类] 0829[工学-安全科学与工程类] 09[农学] 0703[理学-化学类]
核心收录：
D O I：10.1007/s11426-016-0178-7
馆 藏 号：203194269...
