Rational design and functional evolution of targeted peptides for bioanalytical applications

作     者：Yanyan Huang Yulong Jin Rui Zhao 

作者机构：Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Analytical Chemistry for Living BiosystemsInstitute of Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences 

基　　金：supported by the National Natural Science Foundation of China (21375134, 21475140, 21135006, 21321003) The National Basic Research Program of China (2015CB856300) the Chinese Academy of Sciences 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2016年第59卷第10期

页      码：1250-1257页

摘      要：The complicated, highly dynamic and diverse nature of biosystems brings great challenges to the specific analysis of molecular processes of interest. Nature provides antibodies for the specific recognition of antigens, which is a straight-forward way for targeted analysis. However, there are still limitations during the practical applications due to the big size of the antibodies, which accelerate the discovery of small molecular probes. Peptides built from various optional building blocks and easily achieved by chemical synthetic approaches with predictable conformations, are versatile and can act as tailor-made targeting *** this mini review, we summarize the recent developments in the discovery of novel peptides for bioanalytical and biomedical applications. Progresses in peptide-library design and selection strategies are presented. Recent achievements in the peptide-guided detection, imaging and disease treatment are also focused.

主 题 词：分析应用 生物系统 肽库 设计 演变 化学合成方法 生物医学应用 特异性识别 

学科分类：081704[081704] 1001[医学-基础医学] 07[理学] 08[工学] 0817[工学-轻工类] 100102[100102] 070303[070303] 0703[理学-化学类] 10[医学] 

核心收录：

D　O　I：10.1007/s11426-016-0186-x

馆 藏 号：203194329...