Analytical methods for nano-bio interface interactions

作     者：Jing Wang Waseem Akthar Quershi Yiye Li Jianxun Xu Guangjun Nie 

作者机构：CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology 

基　　金：supported by the National Natural Science Foundation of China (21320102003, 31200752, 31661130152, 11435002) the National Distinguished Young Scientists Program (31325010) 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2016年第59卷第11期

页      码：1467-1478页

摘      要：Knowledge on the interactions between engineered nanomaterials(ENMs) and biological systems is critical both for the assessment of biological effects of ENMs and for the rational design of ENM-based products. However, probing the events that occur at the nano-bio interface remains extremely challenging due to their complex and dynamic nature. So far, the understanding of mechanisms underlying nano-bio interactions has been mainly limited by the lack of proper analytical techniques with sufficient sensitivity, selectivity and resolution for characterization of nano-bio interface events. Moreover, many classic bioanalytical methods are not suitable for direct measurement of nano-bio interface interactions. These have made establishing analytical methodologies for systematic and comprehensive study of nano-bio interface one of the most focused areas in nanobiology. In this review we have discussed some representative developments regarding analytical techniques for nano-bio interface characterization, including the improvements of traditional methods and the emergence of powerful new technologies. These developments have allowed ultrasensitive, real-time analysis of interactions between ENMs and biomolecules, transformations of ENMs in biological environment, and impacts of ENMs on living systems on molecular or cellular level.

主 题 词：engineered nanomaterial nano bio interface nano bio interaction analytical methods protein corona synchrotron radiation 

学科分类：07[理学] 070205[070205] 08[工学] 080501[080501] 0805[工学-能源动力学] 080502[080502] 0702[理学-物理学类] 

核心收录：

D　O　I：10.1007/s11426-016-0340-l

馆 藏 号：203208434...