In situ synthesis of gold nanostars within liposomes for controlled drug release and photoacoustic imaging

作     者：Malathi Mathiyazhakan Paul Kumar Upputuri Kathyayini Sivasubramanian Ashish Dhayani Praveen Kumar Vemula 邹培超 浦侃裔 杨诚 Manojit Pramanik 徐臣杰 

作者机构：School of Chemical&Biomedical EngineeringNanyang Technological University62 Nanyang DriveSingapore Institute for Stem Cell Biology and Regenerative Medicine(inStem)GKVK-CampusBellary RoadBangaloreIndia Ramalingaswami Re-Entry FellowDepartment of BiotechnologyNew Delhi 110003India Division of Energy&EnvironmentGraduate School at ShenzhenTsinghua UniversityShenzhen 518055China NTU-Northwestern Institute for NanomedicineNanyang Technological University50 Nanyang AvenueSingapore 

基　　金：supported by NTU-Northwestern Institute for Nanomedicine(To Xu CJ) the Tier-2 Grant funded by the Ministry of Education in Singapore(ARC2/15:M4020238 to M.R) 

出 版 物：《Science China Materials》 (中国科学（材料科学（英文版）)

年 卷 期：2016年第59卷第11期

页      码：892-900页

摘      要：This report describes the design and synthesis of gold nanostars(AuNSs) containing liposomes by the in situ reduction of gold precursor,HAuCU(pre-encapsulated within the liposomes) through HEPES diffusion and *** with the conventional process that encapsulates the pre-synthesized gold nanoparticles into liposomes during the thin-film hydration step,this facile and convenient method allows the formation and simultaneous encapsulation of AuNSs within *** absorption spectra of AuNSs can be tuned between visible and near infra-red(NIR) regions by controlling the size and morphology of AuNSs through varying the concentrations of HAuCU and *** a proof of concept,we demonstrate the synthesis of AuNSs with a maximum absorbance at 803 nm within the temperature-sensitive *** liposomes can produce stronger photoacoustic signals(1.5 fold) in the NIR region than ***,when there are drugs(i.e.,doxorubicin) within these liposomes,the irradiation with the NIR pulse laser will disrupt the liposomes and trigger the 100%release of these pre-encapsulated drugs within 10 *** comparison,there is neglectable contrast enhancement or minor release(10%) of drugs for the pure liposomes under the same ***,cell experiment shows the potential therapeutic application of this system.

主 题 词：gold nanostars light sensitive liposomes controlled drug release photoacoustic imaging 

学科分类：081704[081704] 07[理学] 070205[070205] 08[工学] 0817[工学-轻工类] 080501[080501] 0805[工学-能源动力学] 080502[080502] 0703[理学-化学类] 070301[070301] 0702[理学-物理学类] 

核心收录：

D　O　I：10.1007/s40843-016-5101-3

馆 藏 号：203209868...