DESIGN AND ANALYSIS OF HIGH-THROUGHPUT SCREENING EXPERIMENTS

作     者：Xianggui QU Xianggui QU Department of Mathematics and Statistics,Oakland University,Rochester,MI 48309,USA.

作者机构：Department of Mathematics and Statistics Oakland University Rochester MI 48309 USA. 

出 版 物：《Journal of Systems Science & Complexity》 (系统科学与复杂性学报（英文版）)

年 卷 期：2011年第24卷第4期

页      码：711-724页

摘      要：Saturated row-column designs are studied to eliminate positional effects in primary high- throughput screening experiments. Compared to designs currently used in practice, all compounds in the designs considered are comparable within each microplate in spite of the existence of row and column effects. The designs considered in this paper also have the maximum number of compounds arranged in each microplate. Two statistical methods are used to choose leading compounds in the designs considered. These two methods take full advantages of effect sparsity in primary screening. Simulation studies are carried out to compare the two statistical methods with two ad hoc methods in selecting active compounds. A method that maintains balanced false positives and false negatives is recommended.

主 题 词：Bscore high-throughput screening row-column design saturated design Zscore. 

学科分类：0810[工学-土木类] 1205[管理学-图书情报与档案管理类] 081705[081705] 081401[081401] 08[工学] 0817[工学-轻工类] 0814[工学-地质类] 0811[工学-水利类] 0812[工学-测绘类] 

核心收录：

D　O　I：10.1007/s11424-011-8272-4

馆 藏 号：203210910...