黑人儿童接受心脏移植后的效果不同于白人儿童

作     者：Mahle W.T. Kanter K.R. Vincent R.N. 王经纬 

作者机构：Children's Healthcare of Atlanta Emory University School of Medicine 1405 Clifton Road NE Atlanta GA 30322-1062 United States Dr. 

出 版 物：《世界核心医学期刊文摘（儿科学分册）》 (Dkgest of the World Latest Medical Information)

年 卷 期：2006年第2卷第6期

页      码：23-23页

摘      要：Objective: To examine the relationship of black race to graft survival after heart transplantation in children. Study design: United Network for Organ Sharing records of heart transplantation for subjects < 18 years of age from 1987 to 2004 were reviewed. Analysis was performed using proportional hazards regression controlling for other potential risk factors. Results: Of the 4227 pediatric heart transplant recipients, 717 (17%)-were black. The 1-year graft survival rate did not differ among groups; however, the 5-year graft survival rate was significantly lower for black recipients, 51%versus 69%, P < .001. The median graft survival for black recipients was 5.3 years as compared with 11.0 years for other recipients. Black recipients had a greater number of human leukocyte antigen mismatches, lower median household income, and a greater percentage with Medicaid as primary insurance, P < .001, P < .001, and P < .001. After adjusting for economic disparities, black race remained significantly associated with graft failure, odds ratio = 1.67 (95%CI 1.47 to 1.87), P < .001. Conclusions: Median graft survival after pediatric heart transplantation for black recipients is less than half that of other racial groups. These differences do not appear to be related primarily to economic disparities.

主 题 词：黑人儿童 心脏移植 移植后 平均存活时间 人类白细胞抗原 白人 移植物 回顾性分析 存活率 试验设计 

学科分类：1002[医学-临床医学类] 100210[100210] 100202[100202] 10[医学] 

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