SynBioEcoli： a comprehensive metabolism network of engineered E. coil in three dimensional visualization

作     者：Weizhong Tu Shaozhen Ding Ling Wu Zhe Deng Hui Zhu Xiaotong Xu Chen Lin Chaonan Ye Minlu Han Mengna Zhao Juan Liu Zixin Deng Junni Chen Dong-Qing Wei Qian-Nan Hu 

作者机构：Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences Tianjin 300308 China Wuhan LifeSynther Cooperation Limited Wuhan 430078 China Ministry of Education Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and School of Pharmaceutical Sciences Wuhan University Wuhan 430071 China State Key Laboratory of Software Engineering and School of Computer Sciences Wuhan University Wuhan 430072 China State Key Laboratory of Microbial Metabolism Shanghai Jiao Tong University Shanghai 200240 China 

基　　金：This work was supported by the National Science Foundation of China (Nos. 31270101 and 31570092)  the National High Technology Research and Development Program (No. 2012CB721000) and the Natural Science Foundation of Tianjin  China 

出 版 物：《Frontiers of Electrical and Electronic Engineering in China》 (中国电气与电子工程前沿（英文版）)

年 卷 期：2017年第5卷第1期

页      码：99-104页

摘      要：Background： A comprehensive metabolism network of engineered E. coli is very important in systems biology and metabolomics studies. Many tools focus on two-dimensional space to display pathways in metabolic network. However, the usage of three-dimensional visualization may help to understand better the intricate topology of metabolic and regulatory networks. Methods： We manually curated large amount of experimental data （including pathways, reactions and metabolites） from literature related with different types of engineered E. coli and then utilized a novel technology of three dimensional visualization to develop a comprehensive metabolic network named SynBioEcoll. Results： SynBioEoli contains 740 biosynthetic pathways, 3,889 metabolic reactions, 2,255 chemical compounds manually curated from about 11,000 metabolism publications related with different types of engineered E. coil Furthermore, SynBioEcoli integrates with various informatics techniques. Conclusions： SynBioEcoli could be regarded as a comprehensive knowledgebase of engineered E. coli and represents the next generation cellular metabolism network visualization technology. It could be accessed via web browsers （such as Google Chrome） supporting WebGL, at http：//***/synbioecoli/.

主 题 词：engineered E. coli three dimensional metabolic network biosynthetic ability 

学科分类：12[管理学] 1201[管理学-管理科学与工程类] 08[工学] 

核心收录：

D　O　I：10.1007/s40484-017-0098-1

馆 藏 号：203231843...