Design,synthesis and biological evaluation of novel glucokinase activators

作     者：Yong Qiang Li Yu Liang Zhang Sheng Quan Hu Yu Ling Wang Hong Rui Song Zhi Qiang Feng Lei Lei Quan Liu Zhu Fang Shen 

作者机构：Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050 China School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 China 

基　　金：financially supported by the National Nature Science Foundation of China(No.30572256) 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2011年第22卷第1期

页      码：73-76页

摘      要：A new series of benzamide derivatives as glucokinase activators （GKAs） were designed and synthesized, and their activation for glucokinase were evaluated by the preliminary glucokinase activity assay. The structure-activity relationship （SAR） is discussed. The result shows that compound 12d and 12h have potent activity reference drug RO-28-1675.

主 题 词：Diabetes Glueokinase activators Benzamide derivatives 

学科分类：0710[理学-生物科学类] 071010[071010] 081704[081704] 07[理学] 08[工学] 0817[工学-轻工类] 0805[工学-能源动力学] 080502[080502] 

核心收录：

D　O　I：10.1016/j.cclet.2010.07.023

馆 藏 号：203232684...