Optimization of ionic liquid-based microwave-assisted extraction of polyphenolic content from Peperomia pellucida (L) kunth using response surface methodology

作     者：Islamudin Ahmad Arry Yanuar Kamarza Mulia Abdul Mun'im 

作者机构：Department of Pharmaceutical Sciences Faculty of Pharmacy Mulawarman University Samarinda East Kalimantan Indonesia Department of Pharmaceutical Sciences Faculty of Pharmacy Universitas Indonesia Depok 16424 West Java Indonesia Department of Chemical Engineering Faculty of Engineering Universitas Indonesia Depok 16424 West Java Indonesia 

基　　金：funded by Directorate of Research and Humanity Engagement (DRPM)  Universitas Indonesia via grant “Hibah PITTA 2017” with No. 328/UN2.R3.1/HKP.05.00/ 2017 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2017年第7卷第7期

页      码：660-665页

摘      要：Objective: To optimize the ionic liquid based microwave-assisted extraction(IL-MAE)of polyphenolic content from Peperomia pellucida(L) ***: The IL-MAE factors as experimental design parameters, including microwave power, extraction time, ionic liquid concentration, and liquid–solid ratio had been involved. Response surface methodology and Box–Behnken design were used to obtain predictive model(multivariate quadratic regression equation) and optimization of the extraction process. The response surface was analyzed by using the yields of total polyphenolic content as response ***: Based on the obtained results the optimum extraction condition, including microwave power of 30% Watts, extraction time of 18.5 min, the ionic liquid concentration of 0.79 mol/L, and the liquid–solid ratio of 10.72 mL/g 1-Buthyl-3-methylimidazolium tetrafluoroborate([bmim]BF_4) as a solvent was selected. The regression model was obtained to predicts the yields from Peperomia pellucida:Y = 30.250 – 1.356X_1+ 2.655X_2+ 2.252X_3– 0.565X_4+ 0.990 X_1X_3– 8.172X_1X_4– 3.439 X_3X_4– 4.178 X_1~2– 3.210 X_3~2– 6.786 X_4~2– 7.290 X_1~2X_3+ 5.575X1_X_3~2– 4.843 X_3~2X_4 with R^2= 0.82519. Scale-up confirmation test was obtained the maximum yields of total polyphenolics content with the amount of 31.172 5 mg GAE/***: The IL-MAE method produced a higher extraction polyphenolic and performed rapidly, easily and efficiently.

主 题 词：Peperomia pellucida (L) Kunth 1-buthyl-3-methylimidazolium Tetrafluoroborate 反应表面方法论 Box-Behnken 设计 Polyphenolic 内容 

学科分类：0710[理学-生物科学类] 0831[工学-公安技术类] 1008[医学-中药学类] 1006[医学-中西医结合类] 100602[100602] 10[医学] 

核心收录：

D　O　I：10.1016/j.apjtb.2017.06.010

馆 藏 号：203237210...