Design,synthesis and antimicrobial activities of 1,2,3-triazole derivatives

作     者：Xu Zhao Bo Wei Lu Jun Rui Lu Chun Wei Xin Jian Fa Li Ya Liu 

作者机构：College of Chemistry and Chemical EngineeringTianjin University of TechnologyTianjin 300384China College of ChemistryNankai UniversityTianjin 300071China 

基　　金：supported by the National Natural Science Foundation of China (No. 20976135) 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2012年第23卷第8期

页      码：933-935页

摘      要：Fifteen 1-（4-substituted phenyl）-4-（4-bromophenyl）-5-（halo-o-hydroxyphenyl）imino-1,2,3-triazoles were designed and synthe- sized based on rational combination of 1,2,3-triazoles and （halo）o-hydroxyphenyl group according to the superposition principle of reinforcement of biological activities. All the compounds were tested to an in vitro antimicrobial screening against M.a. and E.c.. Compounds IIe-IIo exhibited more potent antimicrobial activities against M.a. and E.c. than triclosan and fluconazole, which provided valuable information to further study of novel antimicrobial research.

主 题 词：1-(4-Substituted phenyl)-4-(4-bromophenyl)-5-(halo-o-hydroxyphenyl)imino-1,2,3-triazoles 1-(4-Substituted phenyl)-4-(4-bromophenyl)-5-amino-1,2,3-triazoles Synthesis Antimicrobial activity 

学科分类：1007[医学-药学类] 081704[081704] 07[理学] 08[工学] 0817[工学-轻工类] 070303[070303] 0703[理学-化学类] 10[医学] 

核心收录：

D　O　I：10.1016/j.cclet.2012.06.014

馆 藏 号：203242220...