Engineering a customized nanodrug delivery system at the cellular level for targeted cancer therapy

作     者：Jin Li Liping Qiu Sitao Xie Jing Zhang Liqin Zhang Honglin Liu Juan Li Xiaobing Zhang Weihong Tan 

作者机构：Molecular Science and Biomedicine LaboratoryState Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of Life SciencesAptamer Engineering Center of Hunan ProvinceHunan University Center for Research at Bio/Nano InterfaceDepartment of Chemistry and Department of Physiology and Functional GenomicsHealth Cancer CenterUF Genetics Institute and McKnight Brain InstituteUniversity of Florida key Laboratory for Analytical Science of Food Safety and Biology (Ministry of Education)College of ChemistryFuzhou University 

基　　金：supported by the National Natural Science Foundation of China(21505039,2013CB932702) the China National Instrumentation Program(2011YQ03012412) the National Institutes of Health grants(GM079359,CA133086) 

出 版 物：《中国科学：化学英文版》 (Science China(Chemistry))

年 卷 期：2018年第61卷第4期

页      码：497-504页

摘      要：Drug administration customized to individual cells could intrinsically address cancer heterogeneity and provide a safe and effective method for delivering personalized treatment. To accomplish this, we developed a smart nanodrug delivery system characterized by cancer cell-targeted drug delivery and intracellular biomarker-responsive drug activation. This system was composed of a long-nicked DNA duplex formed by tandem hybridization of two extended antisense oligonucleotides whose ends were separately blocked with a cancer cell-specific aptamer, AS1411,and a replaceable anti-biomarker probe(ABP). We demonstrated that this DNA nanodrug was directed to cancer cells with the guidance power of AS 1411 and then activated by the presence of a given intracellular biomarker. By using such a belt-and-braces strategy, this DNA nanodrug system could safely and efficiently accelerate apoptosis of target cancer cells. Moreover, since the expression level of biomarkers tends to indicate the specific physiological state of individual cells, biomarker-responsive activation of the nanodrug is expected to enable customized drug administration at the cellular level.

主 题 词：癌症治疗 水平设计 细胞内 系统 交货 指向 apoptosis aptamer 

学科分类：1007[医学-药学类] 07[理学] 070205[070205] 08[工学] 080501[080501] 0805[工学-能源动力学] 0703[理学-化学类] 0702[理学-物理学类] 10[医学] 

核心收录：

D　O　I：10.1007/s11426-017-9176-3

馆 藏 号：203284751...