The Beijing Desheng Diabetic Eye Study:rationale,design,methodology and baseline data

作     者：Yun-Yun Li Xiu-Fen Yang Hong Gu Xi-Pu Liu Torkel Snellingen Ning-Pu Liu 

作者机构：Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and VisualSciences Key LaboratoryBeijing 100730China Department of OphthalmologyFriendship HospitalCapitalMedical UniversityBeijing 100050China Department of OphthalmologyNingbo Medical TreatmentCenter Lihuili HospitalNingbo 315040Zhejiang ProvinceChina Sekwa Institute of MedicineBeijing 100035China 

基　　金：Supported by the Beijing Natural Science Foundation(No.7131007) the Norwegian Research Council(No.180419/D15/1k) 

出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)

年 卷 期：2018年第11卷第1期

页      码：108-116页

摘      要：AIM： To present the rationale, design, methodology, and the baseline data of the Beijing Desheng Diabetic Eye Study（BDDES）, and to determine the prevalence of diabetic retinopathy（DR） and possible risk factors in patients with type 2 diabetes mellitus（T2DM） in an urban community of Beijing, ***： Community-based prospective cohort study of persons diagnosed with T2DM aged 30 y or older. The main variables of interest are the presence and progression of DR as determined by the standardized ETDRS grading of seven fields fundus photographs. The presence and severity of DR were analyzed for possible correlations to non-genetic and genetic ***： A total of 1438 participants with data available for analysis, the prevalence of any DR was 35.4%. The prevalence of mild non-proliferative diabetic retinopathy（NPDR）, moderate NPDR, severe NPDR, and proliferative diabetic retinopathy was 27.7%, 2.6%, 0.5% and 4.5%, respectively. By multiple logistic regression analysis, risk factors for the presence of any DR included male（P=0.031）, lower income level（P=0.011）, lower education background（P=0.022）, longer duration of diabetes（P=0.001）, younger age at diabetic onset（P=0.001）, higher systolic blood pressure（P=0.007）, higher glycosylated hemoglobin A1 c levels（P=0.001）, high albuminuria（P=0.03）, and use of insulin（P〈0.001）. For vision-threatening DR, four factors were significant： younger age at diabetic onset（P〈0.001）,higher systolic blood pressure（P=0.042）, high albuminuria（P〈0.001）, and use of insulin（P〈0.001）. CONCLUSION： The BDDES is the first large-scale ongoing cohort study of a Chinese urban population of persons with type 2 diabetes. Using standardized grading system comparable to large cohort studies from western populations, our baseline data shows that the prevalence of DR and major risk factors in this Chinese ethnic population are comparable to that found in the western population studies.

主 题 词：type 2 diabetes mellitus diabetic retinopathy risk factors cohort study 

学科分类：1002[医学-临床医学类] 100212[100212] 10[医学] 

核心收录：

D　O　I：10.18240/ijo.2018.01.19

馆 藏 号：203284957...