Different stapling-based peptide drug design:Mimicking α-helix as inhibitors of protein-protein interaction

作     者：Xiang Li Yan Zou Hong-Gang Hu 

作者机构：School of Pharmacy Second Military Medical University 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2018年第29卷第7期

页      码：1088-1092页

摘      要：Peptide stapling strategy has been proven a promising solution in addressing two major pharmacological hurdles, proteolytic stability and membrane permeability, for small peptides as therapeutics. This stapling peptides feature a covalent cross-link of side chains, thus effectively mimicking α-helix as inhibitors of protein-protein interactions. In this review, we category and analyze key examples of various peptide stapling strategies based on different cross-links aligned on the side chain of peptides mainly in the last three years.

主 题 词：Stapling Peptide α-Helix Protein-protein interaction 

学科分类：1007[医学-药学类] 100705[100705] 10[医学] 

核心收录：

D　O　I：10.1016/j.cclet.2018.01.018

馆 藏 号：203290355...