Member of Editorial Board of Rising Stars

作     者：Honglin Li 

作者机构：Professor Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science and Technology 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2018年第36卷第6期

页      码：558-558页

摘      要：Drug Discovery and Design Increasing availability and decreasing costs of computing power, algorithm and software development as well as the fast-growing number of webservers have led to the success of computational lead discovery and drug design. Dr. Honglin Li devotes himself to developing novel computational tools, which are well validated in web lab, to rationalize and improve the efficiency, speed and cost-effectiveness of the drug discovery process. He has made some innovative achievements by combining dry/wet research approaches in drug design, drug interaction mechanism investigation and target identification, etc. 1） For addressing bottlenecks in current drug design methods, he developed several structure- and ligand-based drug design methods, and obtained a series of novel lead compounds during the validation of those methodologies against various targets of diseases such as malaria, T2DM and cancer. After structural optimization with his special expertise and experience in drug design, some modified leads have entered pre-clinical studies. 2） He also developed several in silico target identification and polypharmacology investigation methods or webservers, and identified therapeutically relevant targets for natural products and old drugs with corresponding experimental confirmations, which provided new complementary techniques for drug target deconvolution.

主 题 词：设计方法 软件开发 主角 编委 计算工具 相互作用机制 可获得性 发现过程 

学科分类：01[哲学] 0101[哲学-哲学类] 08[工学] 010108[010108] 0835[0835] 081202[081202] 0812[工学-测绘类] 

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