Synthetic genomes engineered by SCRaMbLEing

作     者：Feng Zhang Daniel F.Voytas 

作者机构：Department of Plant and Microbial Biology University of Minnesota Center for Precision Plant Genomics University of Minnesota Department of Genetics Cell Biology and Development University of Minnesota Center for Genome Engineering University of Minnesota 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2018年第61卷第8期

页      码：975-977页

摘      要：The ability to design and synthesize the genome of a living organism marks one of the most significant achievements in synthetic biology. The first synthetic genomes were those of bacteria （Gibson et al., 2010; Hutchison et al., 2016）, but an international consortium of scientists is now undertaking the ambitious task of designing and synthesizing the entire genome of Saccharornayces cerevisiae, a eukaryotic single-celled yeast （Dymond et al., 2011; Kannan and Gibson, 2017）. One feature of the redesigned yeast genome, called Saccharomyces cerevisiae 2.0 or Sc2.0, is the ability to in-duce novel genetic variation.

主 题 词：合成生物学 染色体 设计 国际协会 真核细胞 基因变化 有机体 科学家 

学科分类：0710[理学-生物科学类] 0830[工学-生物工程类] 07[理学] 08[工学] 09[农学] 071007[071007] 0901[农学-植物生产类] 0836[0836] 090102[090102] 

核心收录：

D　O　I：10.1007/s11427-018-9325-1

馆 藏 号：203306147...