Biothiol-specific fluorescent probes with aggregation-induced emission characteristics

作     者：Siyang Ding Mengjie Liu Yuning Hong 

作者机构：Department of Chemistry and Physics La Trobe Institute for Molecular Science La Trobe University 

基　　金：supported by Australian Research Council (DE170100058) Rebecca L. Cooper Medical Research Foundation 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2018年第61卷第8期

页      码：882-891页

摘      要：Biothiols are important species in physiological processes such as regulating protein structures, redox homeostasis and cell signalling. Alternation in the biothiol levels is associated with various pathological processes, therefore non-invasive fluorescent probes with high specificity to biothiols are highly desirable research utilities. Meanwhile, fluorescent probes with aggregationinduced emission properties(AIEgens) possess unique photophysical properties that allow modulation of the sensing process through controlling the aggregation-disaggregation or the intramolecular rotational motions of the fluorophores. Herein we review the recent progress in the development of biothiol-specific AIEgens. In particular, the molecular design principles to target different types of biothiols and the corresponding sensing mechanisms are discussed, along with the potential of the future design and development of multi-functional bioprobes.

主 题 词：biothiols detection aggregation-induced emission fluorescent probes bioimaging biosensing 

学科分类：081704[081704] 07[理学] 08[工学] 0817[工学-轻工类] 070302[070302] 0703[理学-化学类] 

核心收录：

D　O　I：10.1007/s11426-018-9300-5

馆 藏 号：203307527...