Effect of impeller design on homogeneity, size and strength of pharmaceutical granules produced by high-shear wet granulation

作     者：Zakaria Mirza Jiangtao Liu Yoann Glocheux Ahmad B. Albadarin Gavin M. Walker Chirangano Mangwandi 

作者机构：School of Chemistry and Chemical Engineering Queen's University Belfast Belfast BT9 SAG Northern Ireland UK Synthesis & Solid State Pharmaceuticals Center (SSPC) Department of Chemical and Environmental Science. University of Limerick Ireland 

出 版 物：《Particuology》 (颗粒学报（英文版）)

年 卷 期：2015年第13卷第6期

页      码：31-39页

摘      要：Small mixer impeller design is not tailored for granulation because impellers are intended for a wide range of processes. The aim of this research was to evaluate the performances of several impellers to provide guidance on the selection and design for the purposes of granulation. Lactose granules were produced using wet granulation with water as a binder. A Kenwood KM070 mixer was used as a standard apparatus and five impeller designs with different shapes and surface areas were used. The efficacy of granulate for- mation was measured by adding an optically sensitive tracer to determine variations in active ingredient content across random samples of granules from the same size classes. It was found that impeller design influenced the homogeneity of the granules and therefore can affect final product performance. The vari- ation in active ingredient content across granules of differing size was also investigated. The results show that small granules were more potent than larger granules,

主 题 词：Granule strength Impeller design Homogeneity High-shear granulation Lactose monohydrate 

学科分类：081702[081702] 080704[080704] 08[工学] 0817[工学-轻工类] 0807[工学-电子信息类] 

核心收录：

D　O　I：10.1016/j.partic.2014.12.009

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