Polydentate cyclotriphosphazene ligands:Design,synthesis and bioactivity

作     者：Le Wang Yong Ye Shang Bin Zhong Yu Fen Zhao 

作者机构：Key Laboratory of Chemical Biology and Organic Chemistry Department of Chemistry Zhengzhou University Zhengzhou 450052 China Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education) Department of Chemistry Tsinghua University Beijing 100084 China 

基　　金：supports from the NNSFC(Nos.20602032 20732004 and 20572061) 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2009年第20卷第1期

页      码：58-61页

摘      要：Five multinuclear cyclotriphosphazene ligands were synthesized and tested for their cleavage activities to plasmid DNA. All of these new compounds were confirmed by MS, ^1H NMR, ^31P NMR, ^13C NMR and IR. Preliminary studies on the cleavage of pUC19 DNA in the presence of metal complexes were performed. The results revealed that these complexes could act as powerful catalysts under physiological conditions. The complexes 3b ＋ Cu can effectively cleave DNA to nicked form, giving hydrolysis rate constant of 0.08/h under physiological conditions. An acid-base catalyzed DNA phosphate-diester hydrolysis mechanism was also orooosed.

主 题 词：Cyclotriphosphazene Polydentate ligand DNA cleavage Hydrolysis 

学科分类：090403[090403] 081704[081704] 07[理学] 070304[070304] 08[工学] 0817[工学-轻工类] 09[农学] 0904[农学-动物医学类] 0703[理学-化学类] 

核心收录：

D　O　I：10.1016/j.cclet.2008.10.020

馆 藏 号：203325026...