Utilization of H-bond interaction of nucleobase Uralic with antitumor methotrexate to design drug carrier with ultrahigh loading efficiency and pH-responsive drug release

作     者：Teng-Teng Cai Qi Lei Bin Yang Hui-Zhen Jia Hong Cheng Li-Han Liu Xuan Zeng Jun Feng Ren-Xi Zhuo Xian-Zheng Zhang 

作者机构：Key Laboratory of Biomedical Polymers of Ministry of Education and Department of ChemistryWuhan UniversityWuhan 430072China 

基　　金：This work was supported by the National Key Basic Research Program of China(2011CB606202) National Natural Science Foundation of China(Grant Nos.21374085,21174110 and 51303137) the Fundamental Research Funds for the Central Universities(2042014kf0193) 

出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)

年 卷 期：2014年第1卷第1期

页      码：27-35页

摘      要：A novel Uralic(U)-rich linear-hyperbranched mono-methoxy poly(ethylene glycol)-hyperbranched polyglycerol-graft-Uralic(mPEG-HPG-g-U)nanoparticle(NP)was prepared as drug carrier for antitumor methotrexate(MTX).Due to the H-bond interaction of U with MTX and hydrophobic interaction,this NP exhibited high drug loading efficiency of up to 40%,which was significantly higher than that of traditional NPs based on U-absent copolymers(<15%).In addition,MTX-loaded mPEG-HPG-g-U NPs also demonstrated an acidity-accelerated drug release behavior.

主 题 词：nucleobase Uralic H-bond interaction linear-hyperbranched copolymer drug loading efficiency pH-sensitivity 

学科分类：081704[081704] 07[理学] 08[工学] 0817[工学-轻工类] 070305[070305] 080501[080501] 0805[工学-能源动力学] 0703[理学-化学类] 

D　O　I：10.1093/rb/rbu010

馆 藏 号：203325742...