临床未确诊的多发性硬化患者视神经炎后长期脑MRI改变

作     者：Gal R.L. 黄卫东 

作者机构：Jaeb Center for Health Research 15310 Amberly Dr Tampa FL 33647 United States 

出 版 物：《世界核心医学期刊文摘（神经病学分册）》 (Digest of the World Core Medical Journals:Clinical Neurology)

年 卷 期：2005年第1卷第3期

页      码：12-12页

摘      要：Background: Long term follow up of the Optic Neuritis Treatment Trial (ONTT) cohort to evaluate brain magnetic resonance imaging (MRI) in patients who have not developed clinically definite multiple sclerosis. Objective: To determine th e proportion of patients with monosymptomatic optic neuritis who manifest new br ain MRI lesions without having developed clinically definite multiple sclerosis 10 to 14 years after enrollment in the ONTT. Design: Observational study. Settin g: Fourteen clinical centers. Participants: One hundred eight ONTT patients who had not developed clinically definite multiple sclerosis 10 to 14 years after st udy enrollment. Main Outcome Measure: Development of new T2 lesions on follow u p brain MRI. Results: At least 1 T2 lesion 3 mm or larger was observed on follow up MRIs in 27 (44%) of 61 patients with normal baseline MRIs. Additional lesi ons (≥3 mm) were present on follow up MRIs in 26 (74%) of 35 patients with ab normal baseline MRIs. Conclusions: A subset of patients with monosymptomatic opt ic neuritis manifest neither clinical signs nor MRI evidence of demyelination af ter more than 10 years of follow up. In other cases followed up for this length of time, MRI signal abnormalities may accumulate without causing new clinical m anifestations of multiple sclerosis. This information is useful in counseling pa tients who develop first episode optic neuritis.

主 题 词：多发性硬化 视神经炎 表现正常 内脑 观察性研究 脱髓鞘 临床中心 初发性 治疗试验 试验设计 

学科分类：1002[医学-临床医学类] 100204[100204] 10[医学] 

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