激素、雌激素和替勃龙治疗对绝经后阴道上皮凋亡及cyclinD1表达的影响

作     者：Saǒz N. Ygn O. N.Sgsücel A. Noyan V. Bozdgsz 高雪莲 

作者机构：Kirikkale University Faculty of Medicine Department of Obstetrics and Gynecology Kirikkale Turkey 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2005年第1卷第11期

页      码：15-16页

摘      要：Objective: To investigate the effects of hormone therapy, estrogen therapy and tibolone on markers of apoptosis including bcl-2, and bax and cyclin D 1 expression in postmenopausal vaginal epithelium. Study design: Thirty postmenopausal women were randomized to the treatment protocols (0.625 mg conjugated equine estrogen (CEE) ? 2.5 mg medroxyprogesterone acetate (MPA); 2 mg estradiol valerate; 2.5 mg tibolone). After baseline vaginal biopsy, control biopsies were performed after 70 days following the initiation of the therapy. Bcl-2, bax, Bcl-2/bax ratio, cyclin D1 measurements were performed immunohistochemically. Data were analyzed by Kruskal-Wallis, Mann-Whitney U and Wilcoxon tests. Results: After the treatment period the above-mentioned parameters were not different among the groups except for cyclin D1 levels. Cyclin D1 expression was found to be strong in patients with treated estradiol valerate. Conclusions: The effects of estrogen on cyclin D1 expression were not detected with tibolone or with the addition of progesterone to estrogen in the vaginal epithelium. Cyclin D1 appeared to have stronger effects on the estrogen related proliferation compared to apoptotic markers in vaginal epithelial cells.

主 题 词：替勃龙 cyclinD1 阴道上皮 戊酸雌二醇 醋酸甲羟孕酮 allis Kruskal 数据分析 研究设计 

学科分类：1002[医学-临床医学类] 100211[100211] 10[医学] 

馆 藏 号：203341805...