Selective Cyclooxygenase-2 Inhibitors: Design and Synthesis

作     者：Xin Sheng LEI Zong Ru GUO Ling Bo QU Qi Qing ZHU(Institute of Materia Medica. Chinese Academy of Medical SciencesAnd Peking Union Medical College. Beijing 100050) 

作者机构：Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：1999年第10卷第6期

页      码：469-472页

摘      要：The discovery of COX-2 provides a novel target developing more effective NSAIDs with fewer side effects. On the basis of results from the structure-activity relationships (SAR) of selective COX-2 inhibitors, we have designed and synthesized some promising compounds.

主 题 词：cyclooxygenase cyclooxygenase-2 inhibitor selective 

学科分类：081704[081704] 07[理学] 08[工学] 0817[工学-轻工类] 070303[070303] 0703[理学-化学类] 

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