Optimization strategies for separation of sulfadiazines using Box-Behnken design by liquid chromatography and capillary electrophoresis

作     者：龚文君 张裕平 张毅军 许光日 魏新军 LEE Kwang-pill 

作者机构：Henan Institute of Science and Technology Department of Chemistry Graduate School Kyungpook National University South Korea 

基　　金：Project(20235010) support by the NSFC-KOSEF Scientific Cooperation Program Project supported by the Program for New Century Talents of University in Henan Province Program for Backbone Teacher in Henan Province, China 

出 版 物：《Journal of Central South University of Technology》 (中南工业大学学报（英文版）)

年 卷 期：2007年第14卷第2期

页      码：196-201页

摘      要：Development of effective chromatographic or electrophoretic separation involves judicious deciding of selection of optimal experimental conditions that can provide an adequate resolution at a reasonable run time for the separation of interested components. Box-Behnken factorial design was effectively applied for the separation optimization of eight structurally related sulfonamides using capillary zone electrophorosis and reverse high performance liquid chromatography. Optimum values for volume ratio of THF to H2O in eluent, column temperature and flow rate of eluent are found as 12 to 88, 35℃ and 1.0 mL/min, respectively. Box-Behnken modified optimization model is extended to separation by capillary electrophoresis (CE). While using CE, a satisfactory separation is achieved with a minimum resolution larger than 1.0 for a separation time less than 10 min.

主 题 词：Box-Behnken design high performance liquid chromatography capillary electrophoresis sulfadiazine multi-criteria decision 

学科分类：081704[081704] 07[理学] 08[工学] 0817[工学-轻工类] 070302[070302] 0703[理学-化学类] 

核心收录：

D　O　I：10.1007/s11771-007-0039-7

馆 藏 号：203363085...