Design,synthesis and biological evaluation of novel non-azole derivatives as potential antifungal agents

作     者：Hui Tang Juan Wu Wen Zhang Lei Zhao Ya-Hui Zhang Cheng-Wu Shen 

作者机构：Department of PharmacyShandong Provincial Hospital Affiliated to Shandong University Department of PharmacyGeneral Hospital of PIA Chengdu Military Area Command 

基　　金：supported by the Shandong Natural Science Foundation(No.ZR2012HQ026) the Foundation of Sichuan Provincial Health Department(No.110480) 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2015年第26卷第9期

页      码：1161-1164页

摘      要：A series of 3-substituted quinazolinones,2-substituted quinoxalines and 2-substituted benzopyrans were synthesized and evaluated for their antifungal activity in *** new compounds revealed excellent in vitro antifungal activity with broad *** structure-activity relationships（SARs） of the derivatives were *** 9A2 exhibits better antifungal activity against 5 tested fungi in vitro than fluconazole,especially against Trichophyton rubrum and Microsporum *** study provides a series of novel lead compounds for the development of non-azole antifungal agents.

主 题 词：Non azole Biological evaluation Structure activity relationships Synthesis Antifungal agents 

学科分类：1007[医学-药学类] 081704[081704] 07[理学] 08[工学] 0817[工学-轻工类] 070303[070303] 0703[理学-化学类] 10[医学] 

核心收录：

D　O　I：10.1016/j.cclet.2015.04.030

馆 藏 号：203369259...