OPTIMIZATION OF DESIGN PARAMETERS FOR FLUORESCENCE LAMINAR OPTICAL TOMOGRAPHY

作     者：CHAO-WEI CHEN YU CHEN 

作者机构：Fischell Department of Bioengineering and Electrical and Computer Engineering 2218 Jeong H.Kim BuildingUniversity of Maryland College ParkMD 20742USA 

基　　金：Prevent Cancer Foundation, PCF University of Maryland, Baltimore County, UMBC University of Maryland, UMD State of Maryland 

出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)

年 卷 期：2011年第4卷第3期

页      码：309-323页

摘      要：Laminar optical tomography(LOT)is a mesoscopic tomographic imaging technique ranging between confocal microscopy and diffuse optical tomography(DOT).Fluorescence LOT(FLOT)provides depth-resolved molecular information with 100-200μm resolution over 2-3mm *** this study,we use Monte Carlo simulation and singular-value analysis(SVA)to optimize the source-detector configurations for potential enhancement of FLOT imaging *** effects of different design parameters,including source incidence and detector collection angles,detector number,and sampling density,are *** results indicate that angled incidence/detection configuration might improve the imaging resolution and depth sensitivity,especially for low-scattering *** the number of detectors and the number of scanning steps will also result in enhanced imaging *** also demonstrate that the optimal imaging performance depends upon the background scattering coe±*** result might provide an optimization strategy for FLOT or LOT experimental setup.

主 题 词：Laminar optical tomography(LOT) fluorescence laminar optical tomography(FLOT) singular value analysis(SVA) image reconstruction 

学科分类：0831[工学-公安技术类] 1004[医学-公共卫生预防医学类] 0808[工学-自动化类] 1002[医学-临床医学类] 0809[工学-计算机类] 0805[工学-能源动力学] 100214[100214] 0836[0836] 0702[理学-物理学类] 10[医学] 

核心收录：

D　O　I：10.1142/S1793545811001435

馆 藏 号：203387343...