Current advances in solid free-form techniques for osteochondral tissue engineering

作     者：Joao Bebiano Costa Joana Silva-Correia Rui Luis Reis Joaquim Miguel Oliveira 

作者机构：B's Research Group I3Bs - Research Institute onBiomaterials Biodegradables and Biomimetics University ofMinho Headquarters of the European Institute of Excellenceon Tissue Engineering and Regenerative Medicine AveParkParque de Ciencia e Tecnologia Zona Industrial da Gandra4805-017 Barco Guimaraes Portugal ICVS/3B's-PT Government Associate Laboratory Braga Guimarfies Portugal The Discoveries Centre for Regenerative and PrecisionMedicine Headquarters at University of MinhoAvepark 4805-017 Barco Guimaraes Portugal 

基　　金：European Union’s Horizon 2020 research and innovation program Horizon 2020 Framework Programme, H2020, (734156) Fundação para a Ciência e a Tecnologia, FCT, (IF/00115/2015, IF/01285/2015, PD/BD/113803/2015) 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2018年第1卷第3期

页      码：171-181页

摘      要：Osteochondral （OC） lesions are characterized by defects in two different zones, the cartilage region and subchondral bone region. These lesions are frequently associated with mechanical instability, as well as osteoarthritic degenerative changes in the knee. The lack of spontaneous healing and the drawbacks of the current treatments have increased the attention from the scientific community to this issue. Different tissue engineering approaches have been attempted using different polymers and different scaffolds＇ processing. However, the current conventional techniques do not allow the full control over scaffold fabrication, and in this type of approaches, the tuning ability is the key to success in tissue regeneration. In this sense, the researchers have placed their efforts in the development of solid free-form （SFF） techniques. These techniques allow tuning different properties at the micro-macro scale, creating scaffolds with appropriate features for OC tissue engineering. In this review, it is discussed the current SFF techniques used in OC tissue engineering and presented their promising results and current challenges.

主 题 词：Solid free-form Osteochondral Tissue engineering Scaffolds 

学科分类：0710[理学-生物科学类] 07[理学] 08[工学] 09[农学] 0901[农学-植物生产类] 0836[0836] 090102[090102] 

核心收录：

D　O　I：10.1007/s42242-018-0017-y

馆 藏 号：203395124...