Additive nanomanufacturing of lab-on-a-chip fluorescent peptide nanoparticle arrays for Alzheimer＇s disease diagnosis

作     者：Leming Sun Zhen Fan Tao Yues Jun Yin Jianzhong FU Mingjun Zhang 

作者机构：Department of Biomedical Engineering College ofEngineering Ohio State University Columbus OH 43210USA School of Life Sciences Northwestern PolytechnicalUniversity Xi'an 710072 Shaanxi China Department of Polymeric Materials School of MaterialScience and Engineering Tongji UniversityShanghai 201804 China Institute for Advanced Study TongjiUniversity Shanghai 200092 China School of Mechatronic Engineering and AutomationShanghai University Shanghai 200444 China The State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical Engineering ZhejiangUniversity Hangzhou 310028 China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province School of Mechanical EngineeringZhejiang University Hangzhou 310028 China Dorothy M. Davis Heart & Lung Research Institute The OhioState University Wexner Medical Center Columbus OH43210 USA Interdisciplinary Biophysics Graduate Program Ohio StateUniversity Columbus OH 43210 USA 

出 版 物：《Bio-Design and Manufacturing》 (生物设计与制造（英文）)

年 卷 期：2018年第1卷第3期

页      码：182-194页

摘      要：This paper proposes an additive nanomanufacturing approach to fabricate a personalized lab-on-a-chip fluorescent peptide nanoparticles (f-PNPs) array for simultaneous multi-biomarker detection that can be used in Alzheimer’s disease (AD) diagnosis. We will discuss optimization techniques for the additive nanomanufacturing process in terms of reliability, yield and manufacturing efficiency. One contribution of this paper lies in utilization of additive nanomanufacturing techniques to fabricate a patient-specific customize-designed lab-on-a-chip device for personalized AD diagnosis, which remains a major challenge for biomedical engineering. Through the integrated bio-design and bio-manufacturing process, doctor’s check-up and computer-aided customized design are integrated into the lab-on-a-chip array for patient-specific AD diagnosis. In addition, f-PNPs with targeting moieties for personalized AD biomarkers will be self-assembled onto the customized lab-on-a-chip through the additive nanomanufacturing process, which has not been done before. Another contribution of this research is the personalized lab-on-a-chip f-PNPs array for AD diagnosis utilizing limited human blood. Blood-based AD assessment has been described as “the holy grail” of early AD detection. This research created the computer-aided design, fabrication through additive nanomanufacturing, and validation of the f-PNPs array for AD diagnosis. This is a highly interdisciplinary research contributing to nanotechnology, biomaterials, and biomedical engineering for neurodegenerative disease. The conceptual work is preliminary with intent to introduce novel techniques to the application. Large-scale manufacturing based on the proposed framework requires extensive validation and optimization.

主 题 词：添加剂纳米制造方法 阿尔茨海默病 生物标志物 生物技术 

学科分类：0710[理学-生物科学类] 0831[工学-公安技术类] 07[理学] 0817[工学-轻工类] 0807[工学-电子信息类] 071006[071006] 0805[工学-能源动力学] 0802[工学-机械学] 0836[0836] 0811[工学-水利类] 

核心收录：

D　O　I：10.1007/s42242-018-0019-9

馆 藏 号：203395152...