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Design flaws in randomized, placebo controlled, double blind clinical trials

Design flaws in randomized, placebo controlled, double blind clinical trials

作     者:James David Adams Jr 

作者机构:Department of Pharmacology and Phar-maceutical Sciences University of Southern California School of Pharmacy Los Angeles CA 90089 United States 

出 版 物:《World Journal of Pharmacology》 (世界药理学杂志)

年 卷 期:2012年第1卷第1期

页      码:4-9页

摘      要:The hypothesis in drug clinical trials is that the drug is better than a placebo in patients suffering from a disease. The unstated assumption is that the drug cures the disease or is a powerful treatment for the disease. This is an incorrect assumption. Drugs do not cure or treat diseases. The body heals itself; drugs promote this ability of the body to heal itself. Placebos are assumed to be inactive; however, placebos can also promote the ability of the body to heal itself. Placebos are actually treatments that can stimulate endogenous healing mechanisms. The possible place of placebos in health management is controversial. Clinical trial design should be altered. The hypothesis of clinical trials should be that the drug speeds up or improves the healing of the patient, putting patient healing as the first objective. Placebos should not be used as controls but could be tested as drugs in their own right. The control in clinical trials should be no treatment. Alternatively, new drugs could be compared to existing drugs in clinical trials.

主 题 词:Randomized clinical trials Placebo effect Drug effcacy Healing 

学科分类:1007[医学-药学类] 1006[医学-中西医结合类] 100706[100706] 100602[100602] 10[医学] 

D O I:10.5497/wjp.v1.i1.4

馆 藏 号:203415179...

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