Whole-brain patterns of the presynaptic inputs and axonal projections of BDNF neurons in the paraventricular nucleus

作     者：Fang Luo Yuling Mu Cuicui Gao Yan Xiao Qian Zhou Yiqing Yang Xinyan Ni Wei L.Shen Jiajun Yang 

作者机构：Undergraduate Program and School of Life Science and Technology ShanghaiTech University Institute of Neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences University of Chinese Academy of Sciences Department of Neurology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Department of Neurology Shanghai Sixth People's Hospital East Affiliated to Shanghai University of Medicine & Health Science 

基　　金：funded by the Pudong New Area Science and Technology Development Fund,China (J. Yang,#PKJ2014-Y08) Shanghai University of Medicine & Health Sciences Seed Foundation Project,China (J. Yang,#SPF-18-20-14-006) ational Natural Science Foundation of China (W. Shen,#31771169 and #91857104) Thousand Young Talents Program of China (W. Shen) ShanghaiTech University start-up fund (W. Shen) 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2019年第46卷第1期

页      码：31-40页

摘      要：Brain-derived neurotrophic factor (BDNF) plays a crucial role in human obesity. Yet, the neural circuitry supporting the BDNF-mediated control of energy homeostasis remains largely undefined. To map key regions that might provide inputs to or receive inputs from the paraventricular nucleus (PVN) BDNF neurons, a key type of cells in regulating feeding and thermogenesis, we used rabies virus-based transsynaptic labeling and adeno-associated virus based anterograde tracing techniques to reveal their whole-brain distributions. We found that dozens of brain regions provide dense inputs to or receive dense inputs from PVN BDNF neurons, including several known weight control regions and several novel regions that might be functionally important for the BDNF-mediated regulation of energy ***, several regions show very dense reciprocal connections with PVN BDNF neurons, including the lateral septum, the preoptic area, the ventromedial hypothalamic nucleus, the paraventricular thalamic nucleus, the zona incerta, the lateral parabrachial nucleus, the subiculum, the raphe magnus nucleus, and the raphe pallidus nucleus. These strong anatomical connections might be indicative of important functional connections. Therefore, we provide an outline of potential neural circuitry mediated by PVN BDNF neurons, which might be helpful to resolve the complex obesity network.

主 题 词：BDNF Transsynaptic tracing Obesity Feeding Thermogenesis 

学科分类：10[医学] 

核心收录：

D　O　I：10.1016/j.jgg.2018.11.004

馆 藏 号：203455593...