Rationale and study design for one-stop assessment of renal artery stenosis and renal microvascular perfusion with contrast-enhanced ultrasound for patients with suspected renovascular hypertension

作     者：Jun-Hong Ren Na Ma Si-Yu Wang You-Jing Sun Yue-Wei Zhang Fa-Jin Guo Yong-Jun Li Tian-Hui Li Hu Ai Wen-Duo Zhang Peng Li Wei-Hua Ma Ren Jun-Hong;Ma Na;Wang Si-Yu;Sun You-Jing;Zhang Yue-Wei;Guo Fa-Jin;Li Yong-Jun;Li Tian-Hui;Ai Hu;Zhang Wen-Duo;Li Peng;Ma Wei-Hua

作者机构：Department of SonographyBeijing HospitalNational Center of GerontologyBeijing 100730China Vascular DepartmentBeijing HospitalNational Center of GerontologyBeijing 100730China Nephrology DepartmentBeijing HospitalNational Center of GerontologyBeijing 100730China Department of CardiologyBeijing HospitalNational Center of GerontologyBeijing 100730China Beijing HospitalNational Center of GerontologyBeijing 100730China 

基　　金：supported by grants from the Beijing Hospital Clinical Research 121 Project the Scientific Research Project of Beijing Hospital 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2019年第132卷第1期

页      码：63-68页

摘      要：Background:Renal artery stenosis (RAS) is always associated with abnormalities in renal microvascular perfusion (RMP).However,few imaging methods can simultaneously evaluate the degree of luminal stenosis and ***,this study will aim to evaluate the feasibility of using contrast-enhanced ultrasound (CEUS) for assessing both RAS and RMP to achieve a one-stop assessment of patients with suspected renovascular hypertension. Methods:This will be a single-center diagnostic study with a sample size of *** with chronic kidney disease (CKD) and suspected of having resistant hypertension will be *** with Stages 1–3 CKD will undergo CEUS and computed tomography (CT) angiography (CTA).Values obtained by CEUS and CTA for diagnosing low-grade (lumen reduced by <60%) and high-grade (lumen reduced by ≥60%) RAS will be ***,all patients will also undergo radionuclide *** diagnostic value for RAS will be assessed by the receiver operating characteristic curve,including the accuracy,sensitivity,specificity,positive predictive values,negative predictive values,and area under the *** correlation analysis will be performed to assess the association between CEUS findings for RMP and glomerular filtration rate measured by a radionuclide imaging method. Conclusion:The data gathered from this study will be used to evaluate the feasibility of expanding clinical applications of CEUS for evaluation of patients with suspected renovascular hypertension.

主 题 词：Renovascular hypertension contrast-enhanced ultrasound renal artery stenosis renal microvascular perfusion 

学科分类：10[医学] 

核心收录：

D　O　I：10.1097/CM9.0000000000000002

馆 藏 号：203457674...