Intracellular Self-assembly of TPE-biotin Nanoparticles Enables Aggregation-Induced Emission Fluorescence for Cancer-Targeted Imaging

作     者：Yi-fei Xu Jin-hui Jiang 徐逸飞;蒋金辉

作者机构：Department of Nuclear Medicine The First Aliated Hospital of Anhui Medical University Hefei 230022 China Department of Molecular and Cell Biology University of Leicester Leicester LE1 7RH UK 

基　　金：supported by Anhui Scientific and Technological Project(No.1704a0802164) the Natural Science Foundation of the Anhui Higher Education Institutions of China(No.KJ2018A0192) 

出 版 物：《Chinese Journal of Chemical Physics》 (化学物理学报（英文）)

年 卷 期：2018年第31卷第6期

页      码：851-856,734页

摘      要：Fluorogens with aggregation-induced emission (AIE) characteristics have recently been widely applied for studying biological events, and fluorogens with “smart” properties are especially desirable. Herein, we rationally designed and synthesized a biotinylated and reduction-activatable probe (Cys(StBu)-Lys(biotin)-Lys(TPE)-CBT (1)) with AIE properties for cancer-targeted imaging. The biotinylated probe 1 can be actively uptaken by the biotin receptor-overexpressing cancer cells, and then “smartly” self-assemble into nanoparticles inside cells and turn the fluorescence “On”. Employing this “smart” strategy, we successfully applied probe 1 for cancer-targeted imaging. We envision that this biotinylated intelligent probe 1 might be further developed for cancer-targeted imaging in routine clinical studies in the near future.

主 题 词：Tetraphenylethylene Biotin Self-assembly Aggregation-induced emission 

学科分类：081704[081704] 07[理学] 1001[医学-基础医学] 08[工学] 0817[工学-轻工类] 070302[070302] 0703[理学-化学类] 100106[100106] 10[医学] 

核心收录：

D　O　I：10.1063/1674-0068/31/cjcp1806143

馆 藏 号：203471641...