Drug efficacy and pharmacological action of an organoselenium compound ethaselen,a novel antitumor drug

作     者：傅佳凝 王静瑜 王立辉 王磊 唐菀晨 蔡高雄 刘密 曾慧慧 

作者机构：北京大学医学部天然药物与仿生药物国家重点实验室 药学院化学生物学系北京100191 

基　　金：National Natural Science Foundation of China(Grant No.30472036) 

出 版 物：《Journal of Chinese Pharmaceutical Sciences》 (中国药学（英文版）)

年 卷 期：2010年第19卷第3期

页      码：163-168页

摘      要：Ethaselen, an organoselenium compound designed and synthesized in the School of Pharmaceutical Sciences, Peking University, has been entitled to independent intellectual property rights both at home and abroad. As one of the novel antitumor drugs, ethaselen has been extensively studied in Phase I clinical trial, and its biological target is thioredoxin reductase. In this review, we focus on the ethaselen＇s efficacy and pharmacological actions, including antitumor effects both in vitro and in vivo, and immunologic functions. These research findings not only provide the theoretical basis for the anticancer study of ethaselen, but also guide the clinical trial of ethaselen.

主 题 词：Ethaselen Organoselenium compounds Antitumor effect Immunologic function Thioredoxin reductase 

学科分类：1007[医学-药学类] 1006[医学-中西医结合类] 100706[100706] 100602[100602] 10[医学] 

馆 藏 号：203481029...