羊水栓塞综合征中缓激肽的潜在作用

作     者：Robillard J. Gauvin F. Molinaro G. G.E. Rivard 朱磊 

作者机构：Division d'Hémɑtologie-oncologieHpitɑl Stɑinte-Justine 3175 Cte-Ste-Catherine Montreal Que. H3T 1C5 Canada Dr. 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2006年第2卷第3期

页      码：12-12页

摘      要：Objective: Amniotic fluid embolism is a potentially fatal complication of pregnancy; although several hypotheses have been formulated, the pathophysiology of this condition is not well known. An exaggerated release of bradykinin, which is activated by products of the amniotic fluid that enter the maternal circulation, could explain the symptoms that are present in amniotic fluid embolism. The objective of this study was to assess whether bradykinin is involved in amniotic fluid embolism. Study design: The plasma bradykinin-generating capacity was measured serially in a patient who experienced amniotic fluid embolism. Results: The plasma bradykinin-generating capacity was found to be very low at the time of the initial clinical manifestations, which were characterized by severe hypotension, cardiorespiratory arrest, and coagulopathy. Conclusion: This study suggests a potential role for bradykinin release in the pathophysiology of amniotic fluid embolism.

主 题 词：羊水栓塞 缓激肽 潜在作用 病理生理学 呼吸心跳骤停 凝血功能障碍 研究设计 连续测定 

学科分类：1002[医学-临床医学类] 100211[100211] 10[医学] 

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