Tissue engineered esophagus by copper——small intestinal submucosa graft for esophageal repair in a canine model

作     者：TAN Bo WANG Min CHEN Xi HOU JiangLong CHEN XiaoHe WANG Yue LI-LING Jesse XIE HuiQi 

作者机构：Regenerative Medicine Research Center West China Hospital Sichuan University Laboratory of Stem Cell and Tissue Engineering State Key Laboratory of Biotherapy West China Hospital Sichuan University Department of Orthopedics Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital Department of Thoracic and Cardiovascular Surgery West China Hospital Sichuan University Institute of Genetic Medicine School of Life Sciences Sichuan University 

基　　金：supported by the National Natural Science Foundation of China(31271058 and 81100327) the National High Technology Research and Development Program of China(2012AA020503) 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2014年第57卷第2期

页      码：248-255页

摘      要：Acellular porcine small intestinal submucosa(SIS)has been used for esophagoplasty with success in a canine ***,it did not lead to complete *** better reconstruction,a cellular component is ***,promotion of angiogenesis with copper has been widely recognized by basic research as well as clinical *** this study,we have evaluated the feasibility and effectiveness of combined Cu and SIS(SIS-Cu patch)for the esophageal repair using a canine *** male beagle dogs were subjected to surgical resection to produce cervical esophageal defects(5 cm in length,180°in range).SIS with Cu(5 or 25μmol L 1copper)or without Cu was patched on the esophageal *** esophagram and histology exam were carried out to evaluate the effectiveness of the *** shown,the SIS-Cu graft promoted re-epithelialization,re-vascularization and muscular ***-Cu patch is more effective than SIS alone for esophageal repair,and the SIS+25μmol L 1Cu group demonstrated additional advantages over the SIS+5μmol L 1Cu.

主 题 词：esophagus re-epithelialization re-vascularization muscle regeneration copper small intestinal submucosa 

学科分类：1002[医学-临床医学类] 100210[100210] 10[医学] 

核心收录：

D　O　I：10.1007/s11427-013-4603-0

馆 藏 号：203504580...