Pharmacokinetics of lipoic acid in healthy Chinese volunteers after single and multiple doses of Lipoic acid dispersible tablets

作     者：赵恒利 曹若明 方增军 王海生 Hengli Zhao;Ruoming Cao;Zengjun Fang;Haisheng Wang

作者机构：山东大学第二医院山东济南250033 济南市疾病预防控制中心山东济南250021 

基　　金：Youth Fund of the 2nd Hospital of Shandong University(Grant No.Y2013010075) 

出 版 物：《Journal of Chinese Pharmaceutical Sciences》 (中国药学（英文版）)

年 卷 期：2015年第24卷第5期

页      码：336-341页

摘      要：This study aimed to evaluate the pharmacokinetics for lipoic acid （LA） after oral administration of 12 healthy Chinese volunteers with single and multiple-dose of lipoic acid dispersal tablets using a liquid chromatography-temdend mass spectrometry （LC-MS/MS） methods. In single-dose study, healthy Chinese male and female volunteers received three dose levels at 0.2, 0.3, and 0.4 g of LA dispersal tablets with a 3 x3 Latina square design. In multiple-dose study, 12 healthy Chinese volunteers received orally a 0.1 g of LA dispersible tablet three times daily for 6 consecutive days and 0.3 g once on day 7. The results showed that pharmacokinetics of LA fitted a two-compartment open model. The values of area under the curve （A UC） increased proportionally within the range of 0.2-0.4 g, while the Vd/F, CL/F, MRT, t1/2 and tmax of LA were similar at three dose levels. The steady-state pharmacokinetic parameters of LA were similar to those following a single dose and no accumulation was found following multiple-dose of LA dispersal tablets.

主 题 词：Lipoic acid Pharmacokinetics LC-MS/MS Drug accumulation 

学科分类：1007[医学-药学类] 1006[医学-中西医结合类] 100706[100706] 100602[100602] 10[医学] 

核心收录：

D　O　I：10.5246/jcps.2015.05.043

馆 藏 号：203542559...