Engineering a recombinant chlorotoxin as celltargeted cytotoxic nanoparticles

作     者：Raquel Díaz Laura Sánchez-García Naroa Serna Alejandro Sánchez-Chardi Olivia Cano-Garrido Julieta M.Sánchez Ugutz Unzueta Esther Vazquez Antonio Villaverde 

作者机构：Institut de Biotecnologia i de BiomedicinaUniversitat Autònoma de Barcelona Departament de Genètica i de MicrobiologiaUniversitat Autònoma de Barcelona CIBER de BioingenieríaBiomateriales y Nanomedicina(CIBER-BBN) Servei de MicroscòpiaUniversitat Autònoma de Barcelona Biomedical Research Institute Sant Pau(IIB-Sant Pau)and Josep Carreras Research InstituteHospital de la Santa Creu i Sant Pau Universidad Nacional de CórdobaFacultad de Ciencias ExactasFísicas y Naturales.ICTA and Departamento de QuímicaCátedra de Química Biológica.Córdoba.Argentina.CONICETInstituto de Investigaciones Biológicas y Tecnológicas(IIBYT) 

基　　金：funded by the Agencia Estatal de Investigación(AEI)and Fondo Europeo de Desarrollo Regional(FEDER)(BIO2016-76063-R,AEI/FEDER,UE),AGAUR(2017SGR229) CIBER-BBN(project VENOM4CANCER)granted to Villaverde A,ISCIII(PI15/00272 co-founding FEDER) supported by predoctoral fellowship from AGAUR(2018FI_B2_00051) supported by a predoctoral fellowship from the Government of Navarra supported by PERIS program from the health department of la Generalitat de Catalua 

出 版 物：《Science China Materials》 (中国科学（材料科学（英文版）)

年 卷 期：2019年第62卷第6期

页      码：892-898页

摘      要：Cytotoxic proteins have a wide applicability in human therapies, especially in those conditions that require efficient and selective cell killing, such as cancer. Chlorotoxin (CTX) is a small (4 kDa) basic peptide from the venom of the yellow scorpion Leiurus quinquestriatus , which blocks small-conductance chloride channels thus paralyzing the scorpion prey. Being not extremely potent as a cytotoxin (for instance when compared with ribosome-inactivating proteins), it has gained interest as a targeting agent.

主 题 词：重组DNA技术 细胞毒活性 纳米颗粒 蝎毒素 癌细胞 可生物降解 氯 药物载体 

学科分类：1007[医学-药学类] 07[理学] 070205[070205] 08[工学] 080501[080501] 0805[工学-能源动力学] 0702[理学-物理学类] 10[医学] 

核心收录：

D　O　I：10.1007/s40843-018-9391-y

馆 藏 号：203573168...