Chemical and structural biology of nucleic acids and protein-nucleic acid complexes for novel drug discovery

作     者：GAN JianHua SHENG Jia HUANG Zhen 

作者机构：Department of ChemistryGeorgia State UniversityAtlantaGA 30303USA 

基　　金：financially supported by the Georgia Cancer Coalition(GCC) Distinguished Cancer Clinicians and Scientists and by the US National Science Foundation(NSF MCB-0824837) 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2011年第54卷第1期

页      码：3-23页

摘      要：Since nucleic acids(DNA and RNA) play very important roles in cells,they are molecular targets of many clinically used drugs,such as anticancer drugs and *** of clinical demands for treating various deadly cancers and drug-resistant strains of pathogens,there are urgent needs to develop novel therapeutic *** nucleic acids hasn’t been the mainstream of drug discovery in the past,and the lack of 3D structural information for designing and developing drug specificity is one of the main ***,many important structures of nucleic acids and their protein complexes have been determined over the past decade,which provide novel platforms for future drug design and *** this review,we describe some useful nucleic acid structures,particularly their interactions with the ligands and therapeutic candidates or even *** summarize important information for designing novel potent drugs and for targeting nucleic acids and protein-nucleic acid complexes to treat cancers and overcome the drug-resistant problems.

主 题 词：nucleic acid targets DNA and RNA protein-nucleic acid complexes DNA duplex and junction G-quadruplex ribozyme riboswitch ribosome topoisomerase inhibitors antibiotics structure-based drug design therapeutic agents 

学科分类：0710[理学-生物科学类] 071010[071010] 081704[081704] 07[理学] 08[工学] 0817[工学-轻工类] 0703[理学-化学类] 

核心收录：

D　O　I：10.1007/s11426-010-4174-x

馆 藏 号：203602529...