先兆子痫和正常妊娠中半胱氨酸代谢的基因多态性研究

作     者：Also-Rallo E. Lopez-Quesada E. Urreizti R. M.A. Vilaseca 于洁 

作者机构：Department of Biochemistry Hospital Sant Joan de Déu University of Barcelona Esplugues de Llobregat Barcelona Spain 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2005年第1卷第9期

页      码：5-5页

摘      要：Objective: To evaluate the possible relationship between preeclampsia and poly morphisms in the main genes involved in folate-homocysteine metabolism. Study d esign: Case-control study: 43 patients with preeclampsia and 122 controls witho ut pregnancy complications. Laboratory studies: tHcy and other amino acids, fola te and vitamin B12 and polymorphisms: 677C >T and 1298A >C(MTHFR); 699C >T, 844i ns68 and 1080C >T (CBS); 2756A >G (MTR); and 66G >A, IVS1+766G >A and IVS1+754 A >C (MTRR). Results: Plasma tHcy and folate values were significantly higher (P = 0.004 and P = 0.019), while Met/tHcy ratios were lower (P C polymorphism (MTHFR) with the ratio Met/tHcy (P = 0.014); the 699 C >T polymorphism (CBS) with the ratio tHcy/ΣAA (P = 0.013); the 2756A >G polym orphism (MTR) with tHcy (P = 0.034); and the IVS1+766G >A polymorphism (MTRR) w ith hyperhomocysteinemia (P = 0.012). Conclusion: An association between the pol ymorphisms analysed and preeclampsia could not be demonstrated.

主 题 词：正常妊娠 基因多态性 先兆子痫 妊娠并发症 病例-对照研究 主要基因 高半胱氨酸血症 研究设计 

学科分类：1002[医学-临床医学类] 100211[100211] 10[医学] 

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