联合应用未经保护的胰酶和pH敏感的肠溶衣中心体(药物)不能改善囊性纤维化患者对营养物质的消化吸收

作     者：Kalnins D. Corey M. Ellis L. P.B. Pencharz 郭战宏 

作者机构：Div. of Gastroenterology/Nutrition Hospital for Sick Children 555 University Ave Toronto Ont. M5G 1X8 Canada Dr. 

出 版 物：《世界核心医学期刊文摘（儿科学分册）》 (Dkgest of the World Latest Medical Information)

年 卷 期：2005年第1卷第8期

页      码：32-33页

摘      要：Objectives: To assess the efficacy of combining unprotected powder enzymes an d oral enteric- coated microsphere (ECM) and to ECM alone in treating nutrient maldigestion in patients with cystic fibrosis. Study design: Patients were rando mly assigned into 2 consecutive, 2- week phases; ECM alone, and ECM plus unprot ected powder enzymes. Fecal fat, energy, and nitrogen output were compared with intake at the end of each phase. Two- tailed, paired t tests were performed to compare outcomes. Results: The mean age of the 14 patients (3 girls) was 5.7 ± 3.2 years (range, 1.9 to 13.4 years). There was no significant difference in pe rcent malabsorption of fat (15.6% vs 18.2% ), energy (13.3% vs 13.4% ), or nitrogen (11.8% vs 11.3% ) between phases. Conclusions: The addition of powd er enzymes to ECM did not improve nutrient maldigestion compared with ECM alone.

主 题 词：pH敏感 肠溶衣 囊性纤维化 消化吸收 营养物质 吸收不良 排出量 研究设计 

学科分类：1002[医学-临床医学类] 100202[100202] 10[医学] 

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