Design and evaluation of nicorandil extended-release tablet

作     者：Ju-Young Kim Chun-Woong Park Beom-Jin Lee Eun-Seok Park Yun-Seok Rhee 

作者机构：College of PharmacyWoosuk UniversityWanju-gun 565-701Republic of Korea College of PharmacyChungbuk National UniversityCheongju 361-763Republic of Korea College of PharmacyAjou UniversitySuwon 443-749Republic of Korea School of PharmacySungkyunkwan UniversitySuwon 440-746Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical SciencesGyeongsang National UniversityJinju 660-701Republic of Korea 

基　　金：supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Korean Ministry of Education,Science and Technology(NRF-2012R1A1A1013210) by a grant of the Korean Health Technology R&D Project,Ministry of Health,Welfare&Family Affairs,Republic of Korea(A092018) 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2015年第10卷第2期

页      码：108-113页

摘      要：The aim of this study was to design and evaluate extended-release formulations of a model drug,nicorandil,in order to achieve the desired steady-state plasma concentration of drug in *** was employed to estimate optimum dissolution and absorption rate of *** dissolution test was employed using pH 1.2,4.0,6.8 buffer solution,or water,to measure the in vitro release behaviors of nicorandil formulations.A single dose(15 mg)of each formulation was orally administered to four beagle dogs under fasted conditions,and the pharmacokinetic parameters were *** in vitro/in vivo relationship of the extended-release formulation was confirmed using in vitro dissolution profiles and plasma concentrations of drug in beagle *** was released completely within 30 min from the immediate-release tablets and released for 24 h from the extended-release *** nicorandil plasma concentration could be modified by adjusting the drug release rate from the extended-release *** release rate of nicorandil was the rate-limiting step in the overall absorption of drug from the extendedrelease *** results highlight the potential of a nicorandil extended-release formulation in the treatment of angina pectoris.

主 题 词：Nicorandil In vitro In vivo Pharmacokinetic Extended-release 

学科分类：1007[医学-药学类] 1006[医学-中西医结合类] 100706[100706] 100602[100602] 10[医学] 

核心收录：

D　O　I：10.1016/j.ajps.2014.09.003

馆 藏 号：203615639...