绝经后使用激素与卵巢癌的发病风险

作     者：Moorman P.G. Schildkraut J.M. Calingaert B. 朱国栋 

作者机构：Box 2949 Duke University Medical Center 2424 Erwin Road Durham NC 27710 United States Dr. 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2005年第1卷第11期

页      码：4-5页

摘      要：Objective: The objective of this study was to determine if use of menopausal hormones was associated with ovarian cancer and if risk varied by type of hormone used. Study design: Data from a population-based, case-control study of ovarian cancer in North Carolina (364 cases, 370 controls, all postmenopausal) were analyzed to evaluate the relationship between menopausal hormones and ovarian cancer. logistic regression analyses were used to calculate odds ratios (OR) and 95% CIs associated with various patterns of hormone use. Results: Ovarian cancer cases were more likely than controls to report long-term use (≥ 10 years) of unopposed estrogens (OR 2.2; 95% CI 1.2-4.1). No relationship was observed for estrogen always used with progestin. Conclusion: Hormone replacement therapy used according to current recommendations should not increase risk of ovarian cancer; however, clinicians should be aware of possible increased risk among women with a long history of estrogen replacement therapy.

主 题 词：发病风险 激素替代疗法 病例对照研究 推荐剂量 计算使用 卡莱 研究设计 非对抗性 临床医师 

学科分类：1002[医学-临床医学类] 100214[100214] 10[医学] 

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