Biological identity of nanomaterials:Opportunities and challenges

作     者：DENG Jun YU DaHai GAO ChangYou 

作者机构：MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang University 

基　　金：financially supported by the National Natural Science Foundation of China(51120135001) the National Basic Research Program of China(2011CB606203) Ph.D.Programs Foundation of Ministry of Education of China(20110101130005) Open Project of State Key Laboratory of Supramolecular Structure and Materials(sklssm201303) 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2013年第56卷第11期

页      码：1533-1541页

摘      要：The emergence of nanoparticles(NPs)has attracted tremendous interest of the scientific community for decades due to their unique properties and potential applications in diverse areas,including drug delivery and *** novel NPs have been synthesized and used to reduce drug toxicity,improve bio-availability,prolong circulation time,control drug release,and actively target to desired cells or ***,clinical translation of NPs with the goal of treating particularly challenging diseases,such as cancer,will require a thorough understanding of how the NP properties influence their fate in biological systems,especially in *** efforts have been paid to studying the interactions and mechanisms of NPs and *** deliberately designed,the NPs in contact with biological fluids are rapidly covered by a selected group of biomolecules especially proteins to form a corona that interacts with biological *** this view,the recent development of NPs in drug delivery and the interactions of NPs with cells and proteins are *** understanding the protein-NP interactions,some guidelines for safety design of NPs,challenges and future perspectives are discussed.

主 题 词：纳米材料 生物特性 纳米粒子 相互作用 纳米颗粒 药物输送 生物系统 安全设计 

学科分类：07[理学] 070205[070205] 08[工学] 080501[080501] 0805[工学-能源动力学] 0703[理学-化学类] 0702[理学-物理学类] 

核心收录：

D　O　I：10.1007/s11426-013-4972-z

馆 藏 号：203812050...